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CerebraLux: a low-cost, open-source, wireless probe for optogenetic stimulation.

Robel Dagnew1, Yin-Ying Lin1, Jerikko Agatep1

  • 1University of California, Department of Bioengineering, Los Angeles, California, United States.

Neurophotonics
|October 24, 2017
PubMed
Summary

Researchers developed CerebraLux, a low-cost, wireless optogenetic probe for neuroscience research. This innovative device enables precise neuronal control with enhanced freedom of movement, overcoming limitations of traditional wired systems.

Keywords:
infraredlow costopen sourceoptogeneticswireless optogenetic probe

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optogenetics

Background:

  • Optogenetics is a crucial technique for controlling neuronal activity.
  • Existing optogenetic systems include wired and wireless devices, each with limitations like restricted movement or increased weight.
  • Current systems can be prohibitively expensive for widespread use.

Purpose of the Study:

  • To develop a low-cost, wireless optogenetic probe using readily available components.
  • To provide a detailed description of the device, including design, specifications, and manufacturing methods.
  • To demonstrate the feasibility and utility of the developed probe in a mouse behavioral model.

Main Methods:

  • Designed a two-unit wireless optogenetic probe (CerebraLux) comprising separable optical and electronic components.
  • Utilized off-the-shelf components including a fiber-optic, LED, custom PCB, infrared receiver, microcontroller, and lithium polymer battery.
  • Developed methods for in vivo device application and validated its performance in a mouse behavioral paradigm.

Main Results:

  • Successfully developed CerebraLux, a wireless optogenetic probe weighing 2.8g total (0.5g optical, 2.3g electronic).
  • The device is constructed from affordable, commercially available parts.
  • Demonstrated successful in vivo application and feasibility in a mouse behavioral experiment.

Conclusions:

  • CerebraLux offers a cost-effective and practical wireless solution for optogenetic manipulation.
  • The device design allows for unrestricted movement, overcoming limitations of tethered systems.
  • This innovation has the potential to broaden the accessibility and application of optogenetics in neuroscience research.