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Related Experiment Video

Updated: Feb 20, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

RAS oncogenes direct metastasis.

Magda Spella¹, Antonia Marazioti¹, Kristina A M Arendt²

¹Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.

Molecular & Cellular Oncology

|October 24, 2017

Summary

This summary is machine-generated.

RAS oncogenes drive tumor growth and metastasis. These genes also dictate where cancer spreads by using specific chemokines to signal to endothelial and myeloid cells, defining metastatic tropism.

Keywords:

Chemokines KRAS Lung metastasis Malignant pleural effusion NRAS

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Published on: August 24, 2010

Area of Science:

Oncology
Molecular Biology
Cancer Metastasis Research

Background:

RAS genes are critical oncogenes frequently mutated in various cancers.
Traditionally, RAS oncogenes are known for promoting tumor cell proliferation and survival.
Emerging evidence suggests a role for RAS in determining cancer's metastatic patterns.

Purpose of the Study:

To investigate the role of RAS oncogenes in defining cancer metastatic tropism.
To elucidate the mechanisms by which RAS influences the spread of cancer.
To identify signaling pathways involved in RAS-driven metastasis.

Main Methods:

Analysis of RAS gene mutations across diverse tumor types.
Investigating chemokine signaling pathways.
Studying interactions between cancer cells, endothelial cells, and myeloid cells in metastasis.

Main Results:

RAS oncogenes not only drive tumor growth but also direct metastatic tropism.
RAS-mediated metastasis involves specific sets of chemokines.
These chemokines signal to endothelial and myeloid cells, influencing cancer spread.

Conclusions:

RAS oncogenes play a dual role in cancer, promoting growth and dictating metastatic sites.
Targeting RAS-driven chemokine signaling could offer new strategies for controlling cancer metastasis.
Understanding RAS's role in cellular communication is key to developing effective cancer therapies.