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AFAP1-AS1: A novel oncogenic long non-coding RNA in human cancers
Fuyou Zhang1, Jianfa Li1,2, Huizhong Xiao1,3
1Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, Guangdong Province, China.
Cell Proliferation
|October 24, 2017
Summary
Long non-coding RNAs (lncRNAs) are key in cancer. This review focuses on actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1), a lncRNA overexpressed in many cancers, linking it to disease progression.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are crucial regulators in biological processes and cancer development.
- Many lncRNAs function as oncogenes or tumor suppressors in human malignancies.
- Actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1) is a notable lncRNA implicated in cancer.
Purpose of the Study:
- To review and summarize current research on AFAP1-AS1.
- To elucidate the biological functions and mechanisms of AFAP1-AS1 in human cancers.
- To highlight the role of AFAP1-AS1 in various cancer types and progression.
Main Methods:
- Literature review of studies on AFAP1-AS1.
- Analysis of AFAP1-AS1 expression in different cancer tissues and cell lines.
- Correlation analysis between AFAP1-AS1 expression and clinicopathological features.
Main Results:
- AFAP1-AS1 is overexpressed across a wide spectrum of human cancers, including esophageal, pancreatic, lung, and gastric cancers.
- Elevated AFAP1-AS1 levels are associated with adverse clinicopathological features and cancer progression.
- AFAP1-AS1 exhibits significant roles in cancer biology, acting as a potential oncogene.
Conclusions:
- AFAP1-AS1 is frequently overexpressed in human cancers and linked to poor prognosis.
- Understanding AFAP1-AS1's functions and mechanisms is vital for cancer research.
- AFAP1-AS1 represents a potential therapeutic target in various oncological settings.
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