Type and etiology of pediatric epilepsy in Jordan. A multi-center study
Abdelkarim A Al-Qudah1, Abla Albsoul-Younes, Amira T Masri
1Department of Pediatrics, Faculty of Medicine, University of Jordan, Amman, Jordan.
Insights
This study investigated pediatric epilepsy types and causes in Jordan. Focal seizures were most common, with structural-metabolic issues being the leading etiology.
Area of Science:
- Pediatric Neurology
- Epileptology
- Clinical Research
Background:
- Epilepsy is a common neurological disorder in children.
- Understanding epilepsy types and causes is crucial for effective management.
- The International League Against Epilepsy (ILAE) provides classification guidelines.
Purpose of the Study:
- To classify epilepsy types and determine etiologies in Jordanian pediatric patients.
- To utilize the ILAE 2010 classification for a Jordanian cohort.
- To analyze antiepileptic drug (AED)-treated pediatric epilepsy.
Main Methods:
- Cross-sectional, multi-center study in Jordan.
- Involved 663 pediatric epileptic patients on AEDs.
- Utilized a customized ILAE 2010 classification scheme.
Main Results:
- Focal seizures (53%) were the most prevalent seizure type.
- Structural-metabolic causes accounted for 41.9% of epilepsies.
- Benign epilepsies with centrotemporal spikes were the most common syndrome (27.1%).
Conclusions:
- The study provides insights into pediatric epilepsy in a developing country.
- Findings highlight the importance of structural-metabolic and unknown causes.
- Results have potential international implications for epilepsy classification and research.
Objective:
To study types and etiologies of epilepsy in Jordanian pediatric epileptic patients maintained on antiepileptic drugs using customized classification scheme of International League Against Epilepsy (ILAE) (2010) report.
Methods:
This is a cross-sectional, multi-centre study on pediatric epileptic patients on antiepileptic drugs, who were managed in the pediatric neurology clinics at 6 teaching public hospitals in Jordan.
Results:
Out of the 663 patients included in the study, (90.2%) had one seizure type, (53%) of this type were focal seizures followed by generalized seizures (41.5%) and spasms (5.5%). Distinctive constellations were found in 11/663 (1.7%) patients. Benign epilepsies with centrotemporal spikes were the most common electro clinical syndromes 60/221 (27.1%). Epilepsies attributed to structural-metabolic causes were documented in 278/663 (41.9%) patients, unknown causes 268/663(40.4%) and genetic causes in 117/663(17.7%). Most common causes of structural-metabolic group were due to perinatal insults (32%) and most common causes of the genetic group were the presumed genetic electro clinical syndromes (93.1%).
Conclusion:
Our study is on pediatric epilepsy, using customized classification scheme from the ILAE 2010 report which showed interesting results about type and etiology of epileptic seizures from developing country with potential impact on the international level.
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