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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
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Leukotrienes and kidney diseases
Menachem Rubinstein1, Efrat Dvash
1Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel.
Current Opinion in Nephrology and Hypertension
|October 24, 2017
Summary
Leukotrienes contribute to kidney diseases and drug toxicity. Inhibiting leukotriene C4 (LTC4), a mediator of kidney damage, may offer new treatments for renal diseases and drug-induced nephrotoxicity.
Area of Science:
- Nephrology
- Pharmacology
- Immunology
Background:
- Leukotrienes are implicated in renal diseases and drug nephrotoxicity.
- Recent research reveals mechanisms of cysteinyl leukotriene induction and action in kidney cells.
Purpose of the Study:
- To critically review the role of leukotrienes in renal diseases and drug nephrotoxicity.
- To discuss the mechanism of cysteinyl leukotriene induction and action.
- To propose clinical applications of these findings.
Main Methods:
- Review of existing literature on leukotrienes in renal pathology.
- Analysis of recent studies on leukotriene C4 (LTC4) production in kidney cells.
- Evaluation of the effects of LTC4 inhibitors on drug-induced kidney damage.
Main Results:
- Leukotrienes mediate drug-associated nephrotoxicity, transplant rejection, and renal disease morbidity.
- Cytotoxic agents activate leukotriene C4 (LTC4) production in kidney cells via MGST2.
- LTC4 induces oxidative DNA damage and cell death through NADPH oxidase 4.
- LTC4 inhibitors alleviated drug-induced proximal tubular damage and reduced morbidity in mice.
Conclusions:
- Leukotriene pathways are critical in mediating renal diseases and drug nephrotoxicity.
- Leukotriene inhibitors, used for asthma, show potential for treating drug-induced nephrotoxicity and certain renal diseases.
- Clinical implementation of leukotriene inhibition may offer novel therapeutic strategies for kidney conditions.
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