Related Experiment Video
Updated: Jan 27, 2026
04:04
Asthma Detection Research Based on Voice Signal Processing and Machine Learning
Published on: July 22, 2025
954
Controversies and opportunities in severe asthma
Marc Humbert1,2, William Busse3, Nicola A Hanania4
1Faculté de Médecine, Univ. Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre.
Current Opinion in Pulmonary Medicine
|October 24, 2017
Summary
Identifying distinct severe asthma phenotypes and endotypes is crucial for optimizing treatment. Targeted biologic therapies show promise, while oral corticosteroids should be a last resort, especially in pediatric asthma prevention.
Area of Science:
- Pulmonology
- Immunology
- Pharmacology
Background:
- Many severe asthma patients remain undertreated despite current therapies.
- Understanding asthma phenotypes and endotypes is key to personalized management.
- Current treatments lack a one-size-fits-all approach.
Purpose of the Study:
- To review controversies and opportunities in severe asthma management.
- To highlight the role of targeted therapies and biomarkers.
- To discuss the potential for primary prevention in pediatric asthma.
Main Methods:
- Review of current literature on severe asthma treatments.
- Analysis of biologic therapies targeting specific pathways (e.g., anti-IgE, anti-IL5).
- Discussion of biomarker utility for predicting treatment response.
Main Results:
- Anti-IgE and anti-IL5 biologics are effective and well-tolerated for severe asthma.
- Biomarker-guided use of biologics (e.g., benralizumab, dupilumab) can optimize outcomes.
- Oral corticosteroids are associated with adverse effects and should be a last resort.
Conclusions:
- Further understanding of biomarkers is essential for appropriate biologic use in severe asthma.
- Oral corticosteroids should be reserved for refractory cases due to adverse effects.
- Pediatric severe asthma presents unique opportunities for prevention strategies.
Related Concept Videos
01:29Asthma-I: Introduction
3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
01:26Asthma-II: Pathophysiology and Classification
4.2K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.2K
01:20Asthma: Pathogenesis and Management
1.3K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.3K
01:24Asthma-III: Symptoms and Complications
3.3K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.3K
01:30Asthma-IV: Diagnostic and Management
3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
01:30Asthma-IV: Nursing Management
3.8K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
3.8K