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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Updated: Feb 20, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Metabolomics in asthma: where do we stand?

Helena Pité1,2, Mário Morais-Almeida1, Sílvia M Rocha3

  • 1Allergy Center, CUF Descobertas Hospital and CUF Infante Santo Hospital.

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Metabolomics reveals distinct metabolic signatures in asthma, aiding biomarker discovery and understanding disease mechanisms. Recent advances highlight exhaled volatile organic compounds as promising diagnostic tools for asthma.

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
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Area of Science:

  • Biochemistry
  • Pulmonology
  • Biomarker Discovery

Background:

  • Metabolomics offers insights into asthma's molecular underpinnings.
  • Asthma research increasingly utilizes metabolic profiling for biomarker identification and understanding disease mechanisms.

Purpose of the Study:

  • To review recent advances in metabolomics for asthma research since 2016.
  • To discuss the implications of these findings for future research and clinical practice.

Main Methods:

  • Review of experimental asthma models and clinical studies.
  • Analysis of metabolomics data from human subjects (children and adults).
  • Systematic review with meta-analysis of exhaled volatile organic compounds.

Main Results:

  • Identified common metabolic pathways in asthma: purine, glycerophospholipid, glutathione, fatty acids, and arginine/proline metabolism.
  • Discovered candidate biomarkers for asthma severity and corticosteroid resistance.
  • Highlighted obesity-related asthma phenotypes at the molecular level.
  • Exhaled volatile organic compounds emerged as promising biomarkers for asthma diagnosis and monitoring.

Conclusions:

  • Metabolomics provides novel insights into asthma heterogeneity.
  • Standardization and control of confounding variables are crucial for external validation.
  • Point-of-care technologies are advancing metabolomics for clinical application.
  • Linking metabolites to biological roles is key for targeted therapies and understanding asthma biology.