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Related Concept Videos

Pancreas01:19

Pancreas

2.5K
The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
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Pancreatic Juice and Secretion01:26

Pancreatic Juice and Secretion

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Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
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Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells
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The Pancreatic Expression Database: 2018 update.

Jacek Marzec1, Abu Z Dayem Ullah1, Stefano Pirrò1

  • 1Bioinformatics Unit, Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University London, London EC1M 6BQ, UK.

Nucleic Acids Research
|October 24, 2017
PubMed
Summary
This summary is machine-generated.

The Pancreatic Expression Database (PED) now offers enhanced multi-omics data analysis and literature mining for pancreatic research. These updates improve data integration and visualization, supporting future integration with the Pancreatic Cancer Research Fund Tissue Bank.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Proteomics

Background:

  • The Pancreatic Expression Database (PED) has been a key resource for pancreatic -omics data for over a decade.
  • Existing functionalities include literature mining for pancreatic research.

Purpose of the Study:

  • To present recent updates and the evolution of PED into a comprehensive multi-omics data resource.
  • To introduce a new analytical module for parallel processing alongside literature mining.
  • To prepare PED for integration with the Pancreatic Cancer Research Fund Tissue Bank (PCRFTB).

Main Methods:

  • Integration of multi-omics datasets from major repositories (GEO, ArrayExpress) and initiatives (TCGA, GENIE, CCLE).
  • Development of a new analytical module with functions for tailored data analysis.
  • Implementation of interactive graphics for user-friendly visualization of molecular data.
  • Redesign of the literature-mining module with improved web appearance, query platforms, and annotations.

Main Results:

  • PED now serves as a comprehensive resource for extracting, analyzing, and integrating public multi-omics datasets.
  • The new analytical module enables parallel analysis of diverse pancreatic data.
  • Interactive visualizations allow for intuitive exploration of molecular alterations and relationships.
  • Enhanced literature mining features improve accessibility and annotation of research findings.

Conclusions:

  • The updated PED provides researchers with advanced tools for multi-omics data analysis and integration.
  • These enhancements facilitate deeper insights into pancreatic molecular alterations.
  • PED's evolution supports its upcoming integration with the PCRFTB, furthering pancreatic cancer research.