Related Experiment Video
Updated: Feb 20, 2026
06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
8.9K
CirGRDB: a database for the genome-wide deciphering circadian genes and regulators
Xianfeng Li1, Leisheng Shi2,3, Kun Zhang2,3
1State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan 410078, China.
Nucleic Acids Research
|October 24, 2017
Summary
Disruptions in circadian rhythms negatively impact health. The new CirGRDB database integrates extensive data on circadian RNAs, their regulators, and expression patterns in diseases.
Area of Science:
- Chronobiology
- Genomics
- Bioinformatics
Background:
- Circadian rhythms are crucial for physiological and behavioral functions.
- Disruptions in these rhythms are linked to adverse health outcomes.
- Existing databases lack comprehensive post-transcriptional regulatory information for circadian RNAs.
Purpose of the Study:
- To develop CirGRDB, a database for circadian RNA regulatory information.
- To provide insights into temporal expression patterns of circadian RNAs in various tissues and diseases.
- To facilitate the understanding of transcriptional and post-transcriptional regulation of circadian rhythms.
Main Methods:
- Integrated over 4936 genome-wide assays.
- Developed a user-friendly web interface for searching and browsing data.
- Included data on circadian RNA expression in 37 human/mouse tissues/cell lines and three clinical disorders.
- Incorporated information on eight types of regulatory factors.
Main Results:
- CirGRDB offers temporal expression patterns for circadian genes across diverse human/mouse tissues and cell lines.
- The database includes expression data related to sleep disorders, aging, and tumors.
- It provides information on multiple transcriptional and post-transcriptional regulators, enabling network generation.
Conclusions:
- CirGRDB serves as a valuable resource for studying disease-related circadian RNAs.
- The database aids in deciphering the complex transcriptional and post-transcriptional regulation of circadian rhythms.
- It supports research into the health implications of circadian rhythm disruptions.
Related Concept Videos
02:19Circadian Rhythms and Gene Regulation
4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
02:45Biological Clocks and Seasonal Responses
41.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.8K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
402
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
402