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Related Concept Videos

Human Genetics01:28

Human Genetics

1.7K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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What is Population Genetics?01:25

What is Population Genetics?

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A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.0K
Population Growth00:57

Population Growth

28.8K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
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Related Experiment Video

Updated: Feb 20, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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PopHuman: the human population genomics browser.

Sònia Casillas1, Roger Mulet1, Pablo Villegas-Mirón2

  • 1Institut de Biotecnologia i de Biomedicina and Department de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

Nucleic Acids Research
|October 24, 2017
PubMed
Summary
This summary is machine-generated.

The 1000 Genomes Project provides extensive human genetic variation data. PopHuman is a new genome browser offering interactive visualization of population genetics metrics for evolutionary studies.

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Area of Science:

  • Genomics
  • Population Genetics
  • Bioinformatics

Background:

  • The 1000 Genomes Project (1000GP) is a comprehensive resource of human nucleotide variation.
  • It provides data from 2504 individuals across 26 populations, detailing over 84 million variants.
  • This data is crucial for studying human population genomics and evolutionary dynamics.

Purpose of the Study:

  • To introduce PopHuman, a novel genome browser designed for population genomics.
  • To enable interactive visualization and retrieval of population genetics metrics.
  • To facilitate the analysis of human genetic variation and evolutionary processes.

Main Methods:

  • Development of PopHuman, a genome browser built on JBrowse.
  • Computation of parameter estimates using a novel pipeline tailored for 1000GP data.
  • Estimation of nucleotide variation, divergence, linkage disequilibrium, and neutrality tests across 26 populations.

Main Results:

  • PopHuman provides an extensive inventory of population genetics metrics.
  • Metrics include variation, divergence, linkage disequilibrium, and neutrality tests.
  • Data is analyzed in non-overlapping windows and annotated genes for all 1000GP populations.

Conclusions:

  • PopHuman is a valuable, freely available resource for population genomics research.
  • It enables interactive exploration of human genetic variation and evolutionary history.
  • The browser supports hypothesis testing in molecular population genetics using 1000GP data.