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Related Concept Videos

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Related Experiment Video

Updated: Feb 20, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Brachial artery stiffness estimation using ARTSENS.

V Raj Kiran, P M Nabeel, Jayaraj Joseph

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 25, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Arterial stiffness, a risk factor for heart and kidney disease, can now be measured using the compact ARTSENS® device. This study confirms its reliable and repeatable measurements of brachial artery stiffness.

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    Area of Science:

    • Cardiovascular Physiology
    • Medical Imaging Technology
    • Biomedical Engineering

    Background:

    • Arterial stiffening is a significant risk factor for cardiovascular diseases, including coronary heart disease and kidney disease.
    • Current non-invasive methods for assessing arterial stiffness are often costly, require specialized expertise, and are not suitable for widespread screening.
    • There is a need for accessible, portable, and user-friendly devices for evaluating arterial stiffness.

    Purpose of the Study:

    • To demonstrate the feasibility of using the ARTSENS® device for measuring brachial artery stiffness.
    • To assess the inter-operator repeatability and agreement of ARTSENS® measurements for brachial artery stiffness.
    • To validate the performance of ARTSENS® in a clinical setting.

    Main Methods:

    • ARTSENS®, a compact, image-free ultrasound device, was used to measure arterial stiffness parameters.
    • In-vivo experiments were conducted on 9 healthy subjects, with measurements performed successively by two operators.
    • Key parameters measured included distension, end-diastolic lumen diameter, arterial compliance, and stiffness index for both carotid and brachial arteries.
    • Inter-operator agreement was analyzed using Bland-Altman plots and paired t-tests.

    Main Results:

    • ARTSENS® demonstrated high inter-operator repeatability for brachial artery stiffness measurements.
    • No statistically significant differences were found between measurements made by the two operators (p-values > 0.11 for all parameters).
    • A high and significant correlation (r=0.86, p=0.003) was observed between the measurements made by the two operators.

    Conclusions:

    • The ARTSENS® device is feasible for accurate and repeatable measurement of brachial artery stiffness.
    • The device offers a promising solution for accessible and mass screening of arterial stiffness.
    • ARTSENS® has been validated for carotid artery stiffness and shows potential for broader clinical application in cardiovascular health assessment.