Related Experiment Videos
Do nizatidine and cimetidine interact with ibuprofen?
D R Forsyth1, K S Jayasinghe, C J Roberts
1Department of Medicine, University of Bristol, Bristol Royal Infirmary, UK.
European Journal of Clinical Pharmacology
|January 1, 1988
Summary
This study found that neither nizatidine nor cimetidine, common H2-receptor blockers, affect how the body processes ibuprofen. Ibuprofen pharmacokinetics remained unchanged when taken with these medications.
Area of Science:
- Pharmacology
- Drug Interactions
- Clinical Pharmacology
Background:
- Histamine H2-receptor antagonists are frequently used to reduce gastric acid.
- Potential drug interactions between H2-receptor blockers and non-steroidal anti-inflammatory drugs (NSAIDs) require investigation.
- Ibuprofen is a widely used NSAID for pain and inflammation management.
Purpose of the Study:
- To investigate the pharmacokinetic interaction between ibuprofen and two H2-receptor antagonists: nizatidine and cimetidine.
- To determine if co-administration alters ibuprofen absorption, distribution, metabolism, or excretion.
Main Methods:
- A randomized, three-treatment crossover study was conducted in six healthy male volunteers.
- Subjects received placebo, nizatidine 300 mg, or cimetidine 800 mg daily for six doses.
- Ibuprofen 400 mg was administered on the third day of each treatment period, with serial blood sampling up to 84 hours.
Main Results:
- No significant differences were observed in the area under the plasma concentration-time curve (AUC), rate of absorption, or elimination half-life of ibuprofen across the three treatment groups.
- The elimination half-life of ibuprofen on placebo was 2.04 hours.
- The elimination half-life of nizatidine and cimetidine when co-administered with ibuprofen were 1.72 hours and 3.54 hours, respectively.
Conclusions:
- Neither nizatidine nor cimetidine significantly affects the pharmacokinetics of ibuprofen in healthy male subjects.
- The observed elimination half-life of cimetidine was higher than previously reported, warranting further investigation.
- These findings suggest that concurrent use of ibuprofen with these H2-receptor blockers is unlikely to cause significant pharmacokinetic interactions.