A ROIC for Mn(TPP)Cl-DOP-THF-Polyhema PVC membrane modified n-channel Si3N4 ISFET sensitive to histamine

Area of Science:

• Analytical Chemistry
• Sensor Technology
• Biomedical Engineering

Background:

• Histamine intolerance can cause severe scombroid poisoning.
• Current histamine detection methods are slow, costly, and require skilled technicians.
• Previous research demonstrated ISFETs' potential for histamine detection using a novel membrane.

Purpose of the Study:

• To develop a readout integrated circuit (ROIC) for a histamine-sensing ISFET.
• To create a system for displaying histamine concentration for in-situ applications.
• To enable rapid and accessible histamine level monitoring.

Main Methods:

• Designed a ROIC integrating a novel membrane-modified n-channel Si3N4 ISFET.
• Incorporated constant voltage constant current (CVCC) and amplification circuits.
• Utilized a microcontroller for data processing and LCD display.

Main Results:

• The CVCC circuit successfully maintained constant VDS and followed input voltage.
• The amplification circuit processed signals to a range suitable for microcontroller integration (2.406-4.888V).
• The system accurately classified and displayed histamine safety levels and corresponding voltages.

Conclusions:

• The developed ROIC enables direct voltage output corresponding to histamine concentrations.
• This technology facilitates in-situ histamine monitoring for improved food safety.
• The system offers a promising alternative to traditional, time-consuming detection methods.