Related Experiment Video

Updated: Feb 20, 2026

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
08:04

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol

Published on: November 3, 2023

2.5K

Personalization of a compartmental physiological model for an artificial pancreas through integration of patient's

P Jallon, S Lachal, C Franco

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 25, 2017
    PubMed

    More Related Videos

    Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level11:49

    Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level

    Published on: November 17, 2013

    9.6K
    A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device07:55

    A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device

    Published on: January 26, 2010

    12.4K

    Related Concept Videos

    Mechanistic Models: Overview of Compartment Models01:21

    Mechanistic Models: Overview of Compartment Models

    Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
    416
    Pharmacokinetic Models: Comparison and Selection Criterion01:26

    Pharmacokinetic Models: Comparison and Selection Criterion

    Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
    Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
    393
    Model Approaches for Pharmacokinetic Data: Compartment Models01:14

    Model Approaches for Pharmacokinetic Data: Compartment Models

    Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
    Two primary types of compartment models are recognized: mammillary and catenary. The more...
    607
    Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

    Mechanistic Models: Compartment Models in Individual and Population Analysis

    Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
    288
    Compartment Models: Single-Compartment Model01:14

    Compartment Models: Single-Compartment Model

    The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...
    3.4K
    PI Controller: Design01:24

    PI Controller: Design

    Proportional Integral (PI) controllers are a fundamental component in modern control systems, widely used to enhance performance and mitigate steady-state errors. They are particularly effective in applications such as automatic brightness adjustment on smartphones, where they excel at mitigating steady-state errors for step-function inputs. Unlike PD controllers, which require time-varying errors to function optimally, PI controllers leverage their integral component to address residual...
    1.3K