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Celiprolol and atenolol in angina--effects on left ventricular function
H Dargie1, J M McLenachan, J T Wilson
1Department of Cardiology, Western Infirmary, Glasgow, UK.
The Journal of International Medical Research
|January 1, 1988
Summary
Celiprolol and atenolol both improved stable angina symptoms. Celiprolol demonstrated a unique benefit by prolonging exercise time and potentially offering advantages due to its ancillary properties.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Stable angina pectoris is a common cardiovascular condition.
- Beta-blockers are a cornerstone therapy for angina management.
Purpose of the Study:
- To compare the efficacy and cardiac effects of celiprolol and atenolol in patients with stable angina.
- To investigate the influence of celiprolol's unique pharmacological properties on cardiac function during exercise.
Main Methods:
- A double-blind, placebo-controlled, crossover study involving 16 patients with stable angina.
- Patients received celiprolol (400 mg once daily) and atenolol (100 mg once daily).
- Evaluated angina frequency, exercise tolerance, heart rate, and cardiac output.
Main Results:
- Both celiprolol and atenolol reduced angina frequency and delayed exercise-induced ischemia.
- Only celiprolol significantly prolonged exercise duration.
- Celiprolol caused less heart rate suppression during exercise compared to atenolol.
- Atenolol, but not celiprolol, reduced resting and exercise cardiac output.
Conclusions:
- Celiprolol and atenolol are effective in managing stable angina symptoms.
- Celiprolol's partial beta-2 adrenoceptor agonist and vasodilating activities may confer additional benefits in angina patients.
- These ancillary properties of celiprolol may lead to improved cardiac function and exercise capacity.