A 64-channels neural interface for biopotentials recording and PNS stimulation

Area of Science:

• Biomedical Engineering
• Neuroprosthetics
• Implantable Devices

Background:

• Restoring motor function and sensory feedback in amputees remains a significant challenge.
• Direct interfacing with the peripheral nervous system (PNS) offers a promising avenue for advanced prosthetics.
• Existing systems often lack the integration and compactness required for seamless closed-loop control.

Purpose of the Study:

• To develop a compact, integrated biomedical interface for bidirectional neural interfacing.
• To enable closed-loop control of prosthetic devices, such as robotic hands.
• To restore sensory feedback to amputees by directly interfacing with the PNS.

Main Methods:

• A modular, 16-channel bidirectional unit was designed using 0.35μm bulk-CMOS integrated circuits (ICs).
• The system incorporates a tunable bandwidth recording IC for electroneurography (ENG) and electromyography (EMG) signals.
• A high-voltage (HV) stimulator with a programmable booster (up to 19V) was developed for neural stimulation.

Main Results:

• The recording IC successfully acquired ENG and EMG signals with tunable bandwidth and programmable gain.
• The HV booster effectively increased stimulation voltage to overcome high electrode-tissue impedance.
• In-vivo experiments in rats validated the performance and functionality of the entire system.

Conclusions:

• The developed compact biomedical interface successfully integrates biopotential recording and neural stimulation.
• This bidirectional system holds significant potential for advanced neuroprosthetics, enabling robotic hand control and sensory feedback.
• The modular design and validated in-vivo performance pave the way for future clinical applications in amputee rehabilitation.