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Beta-blocking actions of betaxolol on the isolated rat portal vein
1Department of Pharmacology, School of Medicine, Montevideo, Uruguay.
Fundamental & Clinical Pharmacology
|January 1, 1988
Abstract:
The characteristics of the beta-adrenoceptor population mediating the actions of noradrenaline and isoproterenol in the rat portal vein were examined in comparison with those in the rat atria. In the portal vein, the pA2 values obtained for the selective beta 1-adrenoceptor antagonist betaxolol were 100-fold lower than those obtained in the atria, suggesting that in the rat portal vein a population of beta 2-adrenoceptors is highly predominant.