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Related Experiment Video

Updated: Feb 20, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

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Model evaluation-based approaches for endothelial function.

Naoya Asami, Yoichi Yamazaki, Yoshimi Kamiyama

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 25, 2017
    PubMed
    Summary

    A new mathematical model and simulation technique were developed to evaluate endothelial function using blood flow data. This method accurately reproduces experimental results and provides insights into internal blood vessel states.

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    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Physiology
    • Medical Simulation

    Background:

    • Endothelial dysfunction is a critical indicator of cardiovascular disease.
    • Current methods for assessing endothelial function are often invasive or indirect.
    • Accurate, non-invasive evaluation of endothelial function remains a significant clinical challenge.

    Purpose of the Study:

    • To propose a novel mathematical model and simulation technique for evaluating endothelial function.
    • To simultaneously analyze hemodynamics and vessel wall dynamics for a comprehensive assessment.
    • To establish a method for deriving internal blood vessel states from blood flow information.

    Main Methods:

    • Development of a coupled mathematical model integrating fluid dynamics and solid mechanics.

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    Last Updated: Feb 20, 2026

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  • Implementation of a simulation technique to analyze blood flow and vessel wall interactions.
  • Experimental validation using blood flow data to assess model accuracy.

    • Main Results:

    • The proposed method successfully reproduced experimental blood flow data.
    • The simulation technique demonstrated the capability to analyze hemodynamics and vessel wall dynamics concurrently.
    • Confirmation that the method provides access to internal blood vessel states, which are typically difficult to measure directly.

    Conclusions:

    • The developed mathematical model and simulation technique offer a promising approach for evaluating endothelial function.
    • This method allows for non-invasive assessment of internal blood vessel conditions.
    • The findings suggest potential for improved diagnosis and monitoring of cardiovascular health.