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Related Experiment Video

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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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A generic cardiac biventricular fluid-electromechanics model.

Azam Ahmad Bakir, Amr Al Abed, Nigel H Lovell

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 25, 2017
    PubMed
    Summary

    This study introduces a novel fluid-electromechanics heart model to simulate cardiac function. The model accurately replicates electrical activation, relaxation, and mechanical properties, aiding future research in cardiac multiphysics interactions.

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    Area of Science:

    • Computational Biology
    • Biomedical Engineering
    • Multiphysics Modeling

    Background:

    • Understanding the heart's complex interplay of electrical, mechanical, and fluid dynamics is crucial for diagnosing and treating cardiac diseases.
    • Existing models often simplify or exclude key multiphysics interactions, limiting their predictive capabilities for pathological conditions.

    Purpose of the Study:

    • To develop a fully-coupled fluid-electromechanics model of a generic biventricular heart structure.
    • To create a computational tool for investigating multiphysics interactions within the heart.
    • To simulate realistic cardiac electrical activation, relaxation, and mechanical behaviors.

    Main Methods:

    • A generic biventricular heart model was created with embedded Purkinje fibers and transmural action potential duration variations.
    • Phenomenological action potential and excitation-contraction models were coupled with hyperelastic myocardial material physics.
    • Incompressible Navier-Stokes equations represented blood hemodynamics, enabling simulation of blood-myocardium interactions.

    Main Results:

    • The model achieved realistic electrical activation and relaxation sequences, mimicking physiological cardiac function.
    • Simulated cardiac mechanical properties included torsion and apex displacement, with accurate pressure-volume loops for both ventricles.
    • Vortex formation was observed during the cardiac filling phase, consistent with hemodynamic principles.

    Conclusions:

    • The developed fluid-electromechanics model provides a robust tool for studying biventricular interactions.
    • This model can enhance understanding of cardiac function under pathological conditions.
    • It holds potential for informing the development of improved diagnostic and therapeutic strategies for heart diseases.