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Synthesis and pharmacological effect of substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides
S S Daoud1, S A Osman, M A Karrar
1Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan.
Die Pharmazie
|July 1, 1988
Abstract:
Substituted phenyl-4-(2-chloroethyl)tetrahydro-1,4-oxazine hydrochlorides were prepared by treating the corresponding amino alcohols with thionyl chloride. Since these compounds are considered to be monofunctional 2-haloalkylamine type agents, they were tested for possible alpha-adrenergic blocking activity using the rat anococcygeus muscle. The pharmacological action of this series of compounds is discussed.