Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake.
T Mulder1, M F Q Kluytmans-van den Bergh2,3,4, R M P H Crolla5
1Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands t.mulder-2@umcutrecht.nl.
Antimicrobial Agents and Chemotherapy
|October 25, 2017
Summary
Preoperative oral antibiotics like tobramycin and colistin can prevent surgical site infections in colorectal surgery. This study found minimal risk of toxic side effects from this antibiotic prophylaxis regimen.
Area of Science:
- Surgical Infections
- Pharmacology
- Colorectal Surgery
Background:
- Surgical site infections (SSIs) are a significant complication following colorectal surgery.
- Preoperative oral antibiotic prophylaxis is a strategy to reduce SSI risk.
- Nonabsorbable antibiotics are often used for this purpose.
Purpose of the Study:
- To evaluate the risk of toxic side effects associated with preoperative oral antibiotic prophylaxis.
- To measure postoperative serum tobramycin levels in patients undergoing colorectal surgery.
Main Methods:
- Prospective study design.
- Administration of a 3-day preoperative oral prophylaxis regimen containing tobramycin and colistin.
- Measurement of postoperative serum tobramycin concentrations.
Main Results:
- Serum tobramycin concentrations in all patients were below the detection limit of 0.3 mg/liter.
- This indicates minimal systemic absorption of tobramycin.
Conclusions:
- Preoperative oral prophylaxis with tobramycin and colistin appears to have a low risk of systemic toxicity.
- This regimen may be a safe option for reducing surgical site infections in colorectal surgery.
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