Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake
T Mulder1, M F Q Kluytmans-van den Bergh2,3,4, R M P H Crolla5
1Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands t.mulder-2@umcutrecht.nl.
Abstract:
Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.
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