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Cycloartobiloxanthone Inhibits Migration and Invasion of Lung Cancer Cells

Sucharat Tungsukruthai1,2, Boonchoo Sritularak3, Pithi Chanvorachote4,2

  • 1Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

Anticancer Research
|October 25, 2017
PubMed
Abstract

Insights

The compound cycloartobiloxanthone effectively inhibits lung cancer cell migration and invasion. It suppresses key signaling pathways and epithelial-mesenchymal transition, showing potential for cancer therapy.

Area of Science:

  • Pharmacology
  • Cancer Biology
  • Natural Products

Background:

  • Lung cancer metastasis is a primary cause of mortality.
  • Cancer cell migration and invasion are critical steps in metastasis.
  • Cycloartobiloxanthone from Artocarpus gomezianus exhibits anti-metastatic potential.

Purpose of the Study:

  • To investigate the anti-migration and anti-invasion activities of cycloartobiloxanthone.
  • To elucidate the underlying molecular mechanisms of cycloartobiloxanthone's effects on lung cancer cells.
  • To evaluate the compound's impact on epithelial-mesenchymal transition (EMT) and related signaling pathways.

Main Methods:

  • Human lung cancer H460 cells were treated with cycloartobiloxanthone.
  • Cell viability was assessed using MTT assay.
  • Migration, invasion, filopodia formation, and EMT markers were analyzed via assays and Western blot.

Main Results:

  • Cycloartobiloxanthone demonstrated anti-migration and anti-invasion effects at non-cytotoxic concentrations.
  • The compound reduced filopodia formation and suppressed key signaling proteins like FAK and CDC42.
  • Cycloartobiloxanthone inhibited EMT and decreased expression of migratory integrins (α5, αV, β3).

Conclusions:

  • Cycloartobiloxanthone possesses significant anti-migration and anti-invasion properties against lung cancer cells.
  • The compound acts by inhibiting FAK and CDC42 signaling, reducing filopodia, and suppressing EMT.
  • Cycloartobiloxanthone shows promise for further development as an anti-metastatic agent for lung cancer.
Keywords:
AktCycloartobiloxanthoneintegrininvasionlung cancermigration

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