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Expression of miR-126 and its potential function in coronary artery disease

Xiaoyan Wang1, Yajun Lian2, Xin Wen3

  • 1Department of Ultrasound, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China.

African Health Sciences
|October 25, 2017
PubMed

Insights

MicroRNA-126 (miR-126) is down-regulated in coronary artery disease (CAD) patients. Lower miR-126 levels may indicate CAD, suggesting its potential as a novel biomarker for the condition.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Biomarker Discovery

Background:

  • Coronary artery disease (CAD) poses a significant global health burden.
  • Identifying reliable biomarkers for early detection and management of CAD is crucial.
  • MicroRNAs (miRNAs) are emerging as key regulators in cardiovascular pathophysiology.

Purpose of the Study:

  • To investigate the expression levels of miR-126 in patients with coronary artery disease (CAD).
  • To explore the potential role of miR-126 and its targets in the development of atherosclerosis.
  • To assess the association between miR-126 and clinical indicators in CAD.

Main Methods:

  • Real-time quantitative PCR was employed to measure plasma miR-126 levels in 60 CAD patients and 25 healthy controls.
  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify plasma levels of placenta growth factor (PLGF).
  • CAD patients were stratified into stable angina pectoris (SAP), unstable angina pectoris (UAP), and acute myocardial infarction (AMI) groups.

Main Results:

  • Plasma miR-126 expression was significantly lower in CAD patients compared to healthy controls (P<0.01).
  • Plasma PLGF levels were significantly elevated in patients with UAP and AMI compared to controls (P<0.01).
  • A significant inverse association was observed between miR-126 expression and PLGF levels in patients with AMI.

Conclusions:

  • miR-126 may serve as a novel and valuable biomarker for the diagnosis of coronary artery disease.
  • The down-regulation of miR-126 in CAD suggests its involvement in the atherosclerotic process.
  • Further research is warranted to elucidate the precise mechanisms underlying miR-126's role in CAD.
Abstract

Keywords:
PCRPLGFatherosclerosiscoronary artery diseasemiR-126

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