The Relationship between Body Mass Index (BMI) and Depression According to the rs16139NPY Gene

Objective: Obesity and depression are likely to interact mutually, which makes it unclear whether obesity causes depression or depression leads to obesity, and how the genotypes have a role in obesity and depression. Method: This cross- sectional study was conducted on a sample of 400 individuals from the participants in the third phase of the comprehensive Iranian Multicenter Osteoporosis Study (IMOS). Anthropometric measurements and depression were assessed. PCR-RFLP was used to investigate the NPY polymorphism. Binary logistic regression model was employed to determine depression as the dependent factor and gene polymorphism. Results: The frequency of NPY rs16139 was 6%. No significant association was found between NPY genotypes and depression (p >0.05). Furthermore, the results suggest that those with central obesity had an increased chance of developing depression (P = 0.02). Conclusion: The frequency of NPY polymorphism was 6%. Our study could not find a correlation between rs16139 and depression.