Determining the Factors Associated with Cardiovascular Disease Recurrence: Tehran Lipid and Glucose Study
Samira Taravatmanesh1, Davood Khalili2, Soheila Khodakarim1
1Department of Epidemiology, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
Cardiovascular disease recurrence is linked to age, male sex, smoking, and high blood sugar. These factors, known for initial disease development, also increase the risk of recurrent cardiovascular events.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Cardiovascular disease (CVD) prevention is crucial, yet data on preventing recurrence is limited.
- This study is the first in Iran to investigate factors associated with CVD recurrence.
- Understanding recurrence risk is vital for secondary prevention strategies.
Purpose of the Study:
- To identify and evaluate factors associated with cardiovascular disease recurrence in an Iranian population.
- To analyze the relationship between established CVD risk factors and the incidence of recurrent cardiovascular events.
- To provide insights for targeted interventions aimed at reducing CVD recurrence.
Main Methods:
- A prospective cohort study involving 483 adult participants with a history of CVD.
- Follow-up period of 12 years (1999-2012) within the Tehran Lipid and Glucose Study.
- Statistical analysis to assess the relationship between known CVD risk factors and recurrence.
Main Results:
- The incidence of recurrent cardiovascular events was 48.5 per 100 person-years over the 12-year follow-up.
- Significant predictors of CVD recurrence included older age (HR=1.02), male sex (HR=1.4), current smoking (HR=1.7), and elevated fasting blood sugar (HR=2.1).
- These associations remained significant after controlling for confounding factors.
Conclusions:
- Established risk factors for initial cardiovascular disease, namely age, sex, and smoking, are also significant predictors of CVD recurrence.
- Elevated fasting blood sugar is a critical factor associated with increased risk of cardiovascular disease recurrence.
- These findings underscore the importance of managing traditional risk factors for secondary prevention of cardiovascular disease.
Abstract:
Background: Several studies have emphasized the importance of cardiovascular disease (CVD) prevention. However, there is a dearth of data on the prevention of cardiovascular disease recurrence. The present study was the 1st in Iran to evaluate factors associated with CVD recurrence. Methods: This prospective cohort study was conducted on 483 subjects (> 30 years old) with a history of CVD who participated in the Tehran Lipid and Glucose Study and were followed up for 12 years (1999-2012). The relationships between the most important established risk factors for CVD and CVD recurrence were evaluated. Results: Totally, 258 (53.4%) men and 225(46.5%) women at a mean age of 59.2 ± 10.7 years were recruited in the study. Our results showed that over the 12-year follow-up, the incidence of a recurrent event (per 100 person-years) was 48.5. Further, after controlling the possible confounding factors, the following variables had a significant relationship with CVD recurrence: age (HR = 1.02; p value = 0. 001), male sex (HR = 1.4; p value = 0.012), smoking (HR = 1.7; p value = 0.004), and increased fasting blood sugar (HR = 2.1; p value = 0.001). Conclusion: We found that the established variables in the development of CVD (i.e., age, sex, and smoking) played an important role in the risk of CVD recurrence.
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