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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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Structure-function relationship comparison between retinal nerve fibre layer and Bruch's membrane opening-minimum rim

Lukas Reznicek1, Sophie Burzer1, Andrea Laubichler1

  • 1Department of Ophthalmology, Technical University of Munich, Munich 81675, Germany.

International Journal of Ophthalmology
|October 25, 2017
PubMed
Summary

Glaucoma patients

Keywords:
Bruch's membrane opening-minimum rim widthglaucomamyopiaoptical coherence tomographyretinal nerve fibre layerstandard automated perimetryvisual field defects

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Early detection and monitoring of glaucoma progression are crucial.
  • Structural parameters like RNFL thickness and BMO-MRW are key indicators.

Purpose of the Study:

  • To compare Bruch's membrane opening-minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in glaucoma patients.
  • To correlate these structural parameters with visual field (VF) defects measured by standard achromatic perimetry (SAP).
  • To assess the utility of OCT-based parameters in evaluating glaucoma severity.

Main Methods:

  • Prospective study comparing glaucoma patients with healthy controls.
  • Standard achromatic perimetry (SAP) for visual field testing.
  • SD-OCT for measuring peripapillary RNFL thickness and BMO-MRW.
  • Correlation analyses between structural parameters and mean deviation (MD) values.

Main Results:

  • Significant correlations found between global MD and global RNFL thickness (r=0.632, P=0.001) and global BMO-MRW (r=0.746, P<0.001) in glaucoma patients.
  • Correlations were less significant for sectorial parameters.
  • In myopic glaucoma patients, BMO-MRW showed a tendency for higher correlation with MD than RNFL.

Conclusions:

  • RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma.
  • BMO-MRW may offer higher correlation with VF sensitivity in myopic glaucoma patients.
  • OCT-based structural parameters are valuable in clinical glaucoma assessment.