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Neuronal Intrinsic Physiology Changes During Development of a Learned Behavior.

Matthew T Ross^1,2, Diana Flores³, Richard Bertram^1,3,4

¹Program in Neuroscience, Florida State University, Tallahassee, FL 32306-4301.

|October 25, 2017

Summary

Juvenile zebra finches learn songs via changes in HVC neurons. Intrinsic physiological properties of HVC projection neurons plasticity contribute to vocal learning.

Keywords:

HVC birdsong intrinsic plasticity ion channels modeling zebra finch

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Area of Science:

Neuroscience
Developmental Biology
Bioacoustics

Background:

Song learning in juvenile male zebra finches involves auditory and sensorimotor stages.
The HVC (proper name) nucleus is crucial for both song learning and adult song production.
Synaptic plasticity in HVC is known to change during vocal development.

Purpose of the Study:

To investigate cell-type-specific changes in the intrinsic physiology of HVC projection neurons during vocal development.
To determine if intrinsic neuronal properties, beyond synaptic changes, contribute to song learning.
To model the functional impact of observed physiological changes on HVC circuit activity.

Main Methods:

Patch clamp recordings were used to measure intrinsic membrane properties of HVC neurons in developing zebra finches.
Mathematical models were employed to infer underlying ionic current changes responsible for physiological alterations.
Analysis focused on HVC projection neurons (to basal ganglia and vocal-motor cortex) and HVC interneurons.

Main Results:

HVC neurons projecting to the basal ganglia showed increased voltage sag and rebound depolarization.
HVC neurons projecting to the vocal-motor cortex exhibited a decreased resting membrane potential and increased spike amplitude.
HVC interneurons displayed stable intrinsic physiological features throughout vocal development.

Conclusions:

Developmental plasticity exists in the intrinsic physiology of HVC projection neurons.
These intrinsic plasticity mechanisms may play a significant role in the complex process of song learning.
Changes in intrinsic neuronal properties could significantly influence HVC circuit function during development.