Synbiological systems for complex natural products biosynthesis
Jianhua Li1, Hailin Meng2, Yong Wang1
1Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Synthetic and Systems Biotechnology
|October 25, 2017
Summary
Synthetic biology enables natural product (NP) production but faces challenges in pathway integration. This review covers advances in biological parts, assembly, and optimization for improved NP overproduction.
Area of Science:
- Biotechnology
- Synthetic Biology
- Drug Discovery
Background:
- Natural products (NPs) are crucial in drug discovery.
- Synthetic biology offers engineered NP production strategies.
- Challenges remain in heterologous pathway integration for NP overproduction.
Purpose of the Study:
- To review advancements in synthetic biology for natural product production.
- To highlight progress in biological parts discovery and engineering.
- To discuss pathway engineering and optimization strategies.
Main Methods:
- Review of literature on novel biological parts discovery.
- Analysis of rational design principles for synthetic biological parts.
- Examination of advanced assembly technologies and pathway engineering approaches.
Main Results:
- Progress in discovering and designing biological parts for NP synthesis.
- Improvements in pathway assembly and integration techniques.
- Strategies for optimizing NP production pathways in host cells.
Conclusions:
- Synthetic biology is advancing NP production capabilities.
- Overcoming challenges in pathway integration is key for overproduction.
- Future research should focus on further optimizing engineered pathways.
Keywords:
Biological partsNatural productsSynbiological systemSynthetic biologySystematic optimizationMore Related Videos
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