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Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary

Jin-Ming Cen1, Jie Cheng2, Qing-Yuan Xiong3

  • 1Department of Cardiology, Foshan Municipal First People's Hospital, Foshan, Guangdong 528000, China.

Chronic Diseases and Translational Medicine
|October 25, 2017
PubMed

Insights

Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are elevated in coronary heart disease (CHD) patients. Higher Lp-PLA2 concentrations correlate with increased CHD severity and may synergize with hs-CRP in atherosclerosis.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Inflammation Research

Background:

  • Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
  • Lipoprotein-associated phospholipase A2 (Lp-PLA2) is implicated in atherosclerotic plaque development.
  • Understanding biomarkers for CHD severity is crucial for risk stratification.

Purpose of the Study:

  • To investigate the correlation between plasma Lp-PLA2 levels and coronary heart disease (CHD).
  • To compare plasma Lp-PLA2 concentrations across different CHD subtypes.
  • To explore the relationship between Lp-PLA2 and other cardiovascular risk factors.

Main Methods:

  • Blood samples were collected from 56 CHD patients and 34 healthy controls.
  • Plasma Lp-PLA2 concentrations were measured.
  • Levels of total cholesterol, triglycerides, apolipoproteins, HDL-c, LDL-c, Lp(a), glucose, and hs-CRP were determined.

Main Results:

  • Plasma Lp-PLA2 was significantly higher in all CHD subgroups compared to controls (P < 0.05).
  • Lp-PLA2 levels were highest in acute myocardial infarction (AMI) patients, followed by unstable angina pectoris (UAP), and then stable angina pectoris (SAP) (P < 0.05).
  • Plasma Lp-PLA2 showed a positive correlation with high-sensitivity C-reactive protein (hs-CRP) (r = 0.493, P < 0.05) but not with other tested lipid parameters.

Conclusions:

  • Elevated plasma Lp-PLA2 is associated with CHD.
  • Plasma Lp-PLA2 concentrations vary significantly across different CHD severity levels.
  • Synergistic action between Lp-PLA2 and hs-CRP may contribute to the inflammatory response in atherosclerosis.
Abstract

Keywords:
AtherosclerosisCoronary heart diseasePlasma lipoprotein-associated phospholipase A2

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