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Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population-based

Xiang-Lei Kong1, Xiao-Jing Ma2, Hong Su1

  • 1Department of Nephrology, Qianfoshan Hospital, Shandong University, No.16766, Jingshi Road, Jinan, China.

Chronic Diseases and Translational Medicine
|October 25, 2017
PubMed

Insights

This study found no direct link between occult hepatitis B virus (HBV) infection and chronic kidney disease (CKD). However, monitoring HBV-infected individuals for CKD remains crucial.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Occult hepatitis B virus (HBV) infection is a persistent infection without detectable surface antigen.
  • Previous research on the association between occult HBV infection and chronic kidney disease (CKD) has yielded conflicting results.
  • A clear understanding of this association is needed for effective patient management.

Purpose of the Study:

  • To prospectively investigate the association between occult HBV infection and the development of CKD.
  • To clarify the relationship between occult HBV infection and markers of kidney damage, including reduced estimated glomerular filtration rate (eGFR) and proteinuria.

Main Methods:

  • A prospective cohort study involving 4329 adults without CKD at baseline.
  • Occult HBV infection defined by positivity for antibody to HBV core antigen.
  • CKD defined by eGFR < 60 mL/min/1.73 m² or proteinuria ≥1+ using dipstick method.
  • eGFR calculated using the CKD-EPI equation.

Main Results:

  • The prevalence of occult HBV infection was 8.1%.
  • During 5 years, 3.8% of participants developed CKD.
  • Occult HBV infection was not significantly associated with CKD after adjusting for confounders (OR = 1.12, 95% CI: 0.65-1.95).
  • Hypertension, diabetes, and high uric acid levels were independently associated with CKD.

Conclusions:

  • This study did not establish a significant association between occult HBV infection and the incidence of CKD.
  • Despite the lack of a direct link, continued monitoring for CKD in high-risk individuals with HBV infection is recommended.
Abstract

Keywords:
Chronic kidney diseaseEstimated glomerular filtration rateHepatitis B virusProteinuria

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