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Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease

Shen Gao1, Jing Liu1

  • 1Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

Chronic Diseases and Translational Medicine
|October 25, 2017
PubMed

Insights

Oxidized low-density lipoprotein (ox-LDL) drives atherosclerosis progression, leading to cardiovascular diseases. This review covers ox-LDL

Area of Science:

  • Cardiovascular Science
  • Biochemistry
  • Medical Research

Background:

  • Atherosclerosis is a chronic disease leading to coronary heart disease and stroke.
  • Oxidized low-density lipoprotein (ox-LDL) plays a key role in atherosclerotic cardiovascular disease (ASCVD) progression.

Purpose of the Study:

  • To review the atherogenic mechanisms of ox-LDL.
  • To discuss methods for measuring circulating ox-LDL.
  • To examine the impact of treatments and lifestyle on ox-LDL levels and its association with ASCVD.

Main Methods:

  • Literature review of observational studies.
  • Analysis of studies on ox-LDL measurement techniques.
  • Synthesis of data on therapeutic and lifestyle interventions.

Main Results:

  • Oxidized low-density lipoprotein (ox-LDL) is a significant factor in ASCVD development.
  • Various methods exist for measuring circulating ox-LDL.
  • Medical therapies and lifestyle changes can influence ox-LDL levels.

Conclusions:

  • Circulating ox-LDL levels are associated with both clinical ASCVD events and subclinical atherosclerosis.
  • Understanding ox-LDL is crucial for managing and preventing cardiovascular diseases.

Keywords:
AtherosclerosisCardiovascular diseaseOxidized low density lipoproteinReviewSubclinical atherosclerosis

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