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Updated: Feb 20, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
[Regulation of vascular function by nitric oxide-related S-nitrosylation]
Jing Li1, Juan Feng2, Xian Wang3
1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China.
Abstract:
Nitric oxide (NO), well known as the endothelium-derived relaxing factor (EDRF), has become increasingly recognized as an important determinant of cardiovascular diseases. A molecular pathway by which NO accomplishes various biochemical processes is the cGMP-independent post-translational modification of protein, S-nitrosylation. Here we review the biochemistry and regulating mechanisms of NO-related S-nitrosylation of proteins, and discuss the multiple roles of S-nitrosylation in vascular functions and pathology in particular.
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