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Updated: Feb 20, 2026

Immunohistochemical and Calcium Imaging Methods in Wholemount Rat Retina
Published on: October 13, 2014
[Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells]
Shao-Liu Wang1, Wen-Jing Qian2, Xiao-Han Wang2
1Luoyang Vocational and Technical College, Luoyang 471000, China.
Abstract:
Endocannabinoid receptor system is extensively expressed in the vertebrate retina. There are two types of cannabinoid receptors, CB1 and CB2. Activation of these two receptors by endocannabinoids N-arachidonoylethanolamide (anandamine, AEA) and 2-arachidonyl glycerol (2-AG) regulates multiple neuronal and glial ion channels, thus getting involved in retinal visual information processing. In this review, incorporating our results, we discuss the modulation of cannabinoid CB1 and CB2 receptors on retinal neuronal and glial ion channels and retinal synaptic transmission.
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