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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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[DREAM: a multifunctional transcriptional regulator].

Zi-Bing Fu1, Xu-Bo Duan1,2, Li-Na Li1

  • 1Laboratory of Functional Study of Astrocytes, Peking University Neuroscience Research Institute, Department of Neurobiology, School of Basic Medical Sciences, Peking University; Key Laboratory for Neuroscience, Ministry of Education; National Health and Family Planning Commission, Beijing 100191, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
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Summary

Downstream regulatory element antagonist modulator (DREAM) is a neuronal calcium sensor protein that regulates gene transcription. It plays roles in pain, learning, memory, and neurological diseases like Alzheimer's.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • DREAM, Calsenilin, and KChIP3 are neuronal calcium sensor (NCS) superfamily members.
  • These proteins are encoded by the same gene locus but have distinct subcellular locations.
  • DREAM regulates gene transcription by interacting with DNA elements and transcription factors.

Purpose of the Study:

  • To review the discovery, structure, and function of DREAM.
  • To focus on DREAM's nuclear translocation and gene transcription regulation mechanisms.
  • To highlight DREAM's involvement in neurological processes and diseases.

Main Methods:

  • Literature review of existing studies on DREAM.
  • Analysis of DREAM's interaction with DNA and transcription factors.
  • Examination of DREAM's role in calcium signaling and gene regulation.

Main Results:

  • DREAM binds to downstream regulatory elements (DRE) to suppress gene transcription.
  • Calcium binding to DREAM's EF-hand motifs disrupts DRE interaction.
  • DREAM interacts with CREB, CBP, and CREM to modulate gene expression.
  • DREAM is primarily expressed in the central nervous system, particularly the cerebellum.

Conclusions:

  • DREAM is a key regulator of gene transcription influenced by intracellular calcium levels.
  • DREAM's functions extend to pain sensitivity, learning, memory, and neurodegenerative diseases.
  • Understanding DREAM's mechanisms is crucial for potential therapeutic interventions in neurological disorders.