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Updated: Feb 20, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
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[Neuromodulation of lower urinary tract dysfunction].

T M Kessler1, S de Wachter2

  • 1Neuro-Urologie, Zentrum für Paraplegie, Universitätsklinik Balgrist, Universität Zürich, Forchstraße 340, 8008, Zürich, Schweiz. tkessler@gmx.ch.

Der Urologe. Ausg. A
|October 25, 2017
PubMed
Summary
This summary is machine-generated.

Neuromodulative procedures like transcutaneous electrical nerve stimulation (TENS) and sacral neuromodulation (SNM) offer effective treatments for refractory lower urinary tract dysfunction and bowel issues, with ongoing developments expected to increase their importance in urology.

Keywords:
Bowel dysfunctionChronic urinary retentionNerve stimulationOveractive bladder syndromeSpinal reflex

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Area of Science:

  • Urology
  • Neurology
  • Physiology

Background:

  • Refractory lower urinary tract dysfunction and bowel dysfunction present significant clinical challenges.
  • Neuromodulative procedures are emerging as promising second-line therapeutic options for these conditions.

Purpose of the Study:

  • To review the efficacy and potential mechanisms of neuromodulative procedures in treating lower urinary tract and bowel dysfunction.
  • To highlight the growing importance of these techniques in urological practice.

Main Methods:

  • Review of neuromodulative procedures including transcutaneous electrical nerve stimulation (TENS), transcutaneous/percutaneous tibial nerve stimulation (TTNS/PTNS), and sacral neuromodulation (SNM).
  • Discussion of proposed mechanisms involving peripheral afferent modulation of spinal cord reflexes and brain networks.

Main Results:

  • Neuromodulative therapies demonstrate potential for successfully treating both storage and voiding lower urinary tract disorders, as well as bowel dysfunction.
  • These procedures may be particularly effective in complex and desperate clinical situations.

Conclusions:

  • Neuromodulation, through mechanisms not yet fully understood, offers a viable treatment avenue for refractory lower urinary tract and bowel dysfunction.
  • Continued advancements in neuromodulative techniques are anticipated to significantly expand their role in urology.