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Updated: Feb 20, 2026
13:08
Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
Published on: August 10, 2017
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Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking
Leslie K Climer1, Rachel D Hendrix2, Vladimir V Lupashin3
1College of Medicine, Physiology and Biophysics, UAMS, Little Rock, AR, USA.
Handbook of Experimental Pharmacology
|October 25, 2017
Summary
The conserved oligomeric Golgi (COG) complex is vital for neuronal cell function, but its roles in different compartments remain unclear. COG defects lead to congenital disorders of glycosylation (CDG) type II.
Area of Science:
- Cell Biology
- Neuroscience
- Biochemistry
Background:
- The conserved oligomeric Golgi (COG) complex is crucial for Golgi apparatus functions, including glycosylation and protein sorting.
- COG is present in neuronal cells, yet its specific roles in various Golgi-like compartments are not fully understood.
Purpose of the Study:
- To review and analyze recent findings on Golgi and Golgi-like compartments in neuronal cells.
- To elucidate the functions and dysfunctions of the COG complex and its associated proteins in neuronal contexts.
Main Methods:
- Literature review and critical analysis of recent research.
- Synthesis of data on COG complex function in neuronal cells.
Main Results:
- COG complex is essential for neuronal cell Golgi functions like protein and lipid glycosylation and sorting.
- Alterations in COG subunits impact Golgi morphology, protein trafficking, and glycosylation.
- COG complex dysfunction is linked to congenital disorders of glycosylation (CDG) type II.
Conclusions:
- Further research is needed to fully understand COG complex functions in diverse neuronal Golgi-like compartments.
- Understanding COG complex roles is critical for addressing neurological disorders associated with glycosylation defects.
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