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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Traumatic Memory01:20

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Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Updated: Feb 20, 2026

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MicroRNAs in Post-traumatic Stress Disorder.

Clara Snijders1, Laurence de Nijs1, Dewleen G Baker2,3,4

  • 1Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, European Graduate School of Neuroscience, (EURON), Maastricht, 6200 MD, The Netherlands.

Current Topics in Behavioral Neurosciences
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PubMed
Summary

Investigating microRNAs (miRNAs) in post-traumatic stress disorder (PTSD) reveals their potential role in stress response. Further research is needed to understand these epigenetic mechanisms in humans.

Keywords:
BrainEpigeneticsPost-traumatic stress disorderReviewmicroRNA

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Area of Science:

  • Neuroscience and Psychiatry
  • Epigenetics
  • Molecular Biology

Background:

  • Post-traumatic stress disorder (PTSD) affects a minority of trauma-exposed individuals, highlighting the need to understand susceptibility mechanisms.
  • Epigenetic factors, particularly non-coding RNAs (ncRNAs) like microRNAs (miRNAs), are emerging as key players in the long-term effects of trauma.
  • Current research on miRNAs in PTSD is limited, primarily using animal models and cross-sectional designs focusing on susceptible phenotypes.

Purpose of the Study:

  • To provide a comprehensive review of existing studies on the role of miRNAs in PTSD.
  • To identify current challenges and limitations in miRNA research related to PTSD.
  • To discuss future research perspectives, emphasizing translational and longitudinal approaches.

Main Methods:

  • Systematic review of published literature on miRNAs and PTSD.
  • Analysis of study designs, animal models, and phenotypic focus in existing research.
  • Identification of research gaps and methodological limitations.

Main Results:

  • The review synthesizes current knowledge on miRNAs implicated in PTSD.
  • Significant limitations exist in current research, including reliance on animal models and cross-sectional data.
  • A need for human-based, longitudinal studies comparing susceptible and resilient individuals is evident.

Conclusions:

  • MicroRNAs are a promising area for understanding the biological underpinnings of PTSD susceptibility and resilience.
  • Future research should adopt translational, cross-species, and longitudinal designs to elucidate miRNA functions in PTSD.
  • Addressing current challenges is crucial for advancing the field and developing effective interventions.