Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.2K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.2K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.0K
Immunological Memory01:23

Immunological Memory

17.2K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.2K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

17.1K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.6K
Overview
84.6K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

10.1K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of Zinc on T Cell Motility and the Immunological Synapse.

International journal of molecular sciences·2026
Same author

A 3-Year Split-Mouth Randomized Controlled Clinical Trial of Zirconia and Titanium Implant-Supported Overdentures.

Journal of functional biomaterials·2026
Same author

Reduced interleukin-2 production and increased CREMα protein expression in vegetarians and vegans due to zinc deficiency.

The Journal of nutritional biochemistry·2026
Same author

Advances in automatic airborne fungal spore monitoring: detection-efficiency test of the BAA500.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Proliferation-associated protein 2G4 promotes keratinocyte proliferation and survival in psoriasis.

The British journal of dermatology·2026
Same author

Plasma Desmosine Is Elevated in Thoracoabdominal Aortic Aneurysms and Is Associated with Intramural Proteolytic Activity.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Feb 20, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

39.3K

Zinc Signals and Immunity.

Martina Maywald1, Inga Wessels2, Lothar Rink3

  • 1Institute of Immunology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074 Aachen, Germany. martina.maywald@rwth-aachen.de.

International Journal of Molecular Sciences
|October 25, 2017
PubMed
Summary
This summary is machine-generated.

Maintaining proper zinc levels is vital for immune function. This review details how zinc impacts immune cell signaling, affecting susceptibility to infections and inflammatory diseases.

Keywords:
homeostatic zinc signalimmune functioninnate and adaptive immunitysignaling pathwayszinc deficiencyzinc fluxzinc wave

More Related Videos

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
07:55

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality

Published on: June 2, 2023

1.7K
Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria
08:24

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria

Published on: September 20, 2024

922

Related Experiment Videos

Last Updated: Feb 20, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

39.3K
Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
07:55

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality

Published on: June 2, 2023

1.7K
Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria
08:24

Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria

Published on: September 20, 2024

922

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Zinc homeostasis is essential for immune system function.
  • Imbalances in zinc (deficiency or excess) disrupt immune cell activity and numbers.
  • This can lead to increased infection susceptibility and inflammatory conditions.

Purpose of the Study:

  • To review the role of zinc in intracellular signaling pathways within immune cells.
  • To highlight molecular mechanisms and targets affected by zinc homeostasis.
  • To emphasize the interplay between zinc and redox metabolism in immune signaling.

Main Methods:

  • Literature review focusing on zinc's role in innate and adaptive immunity.
  • Analysis of molecular targets including kinases, caspases, phosphatases, and phosphodiesterases.
  • Distinguishing between rapid zinc fluxes, zinc waves, and late homeostatic signals.

Main Results:

  • Zinc regulates key signaling pathways in various immune cell types.
  • Altered zinc homeostasis affects intracellular signaling molecules and processes.
  • The interplay of zinc and redox metabolism significantly influences immune cell function.

Conclusions:

  • Zinc is a critical regulator of immune cell signaling and function.
  • Understanding zinc's role in signaling pathways is crucial for addressing immune disorders.
  • Further research into zinc's dynamic signaling (fluxes, waves) can reveal new therapeutic targets.