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Related Experiment Video

Updated: Feb 20, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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Near-Infrared Light Triggered Upconversion Optogenetic Nanosystem for Cancer Therapy.

Bin Zheng1, Hanjie Wang1, Huizhuo Pan1

  • 1School of Life Sciences, Tianjin University , 92 Weijin Road, Nankai District, Tianjin 300072, China.

ACS Nano
|October 25, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces upconversion optogenetic nanosystems using rare-earth nanoparticles to convert near-infrared light into blue light for deep-tissue optogenetic manipulation, enabling noninvasive control of cancer cell apoptosis in vivo.

Keywords:
apoptosiscancer therapynear-infrared (NIR) lightoptogenetic manipulationupconversion nanoparticles

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Optogenetics

Background:

  • Optogenetic manipulation in deep tissues is limited by visible light's poor penetration.
  • Activating photoactuators in vivo requires efficient light delivery to target sites.

Purpose of the Study:

  • To design a versatile upconversion optogenetic nanosystem for deep-tissue manipulation.
  • To enable noninvasive, in vivo optogenetic control using near-infrared light.

Main Methods:

  • Development of a nanosystem integrating rare-earth upconversion nanoparticles (UCNs) with a blue-light-mediated heterodimerization module.
  • Utilizing UCNs to convert near-infrared (NIR) light into blue light for photoreceptor activation.
  • Demonstration of in vivo optogenetic control in mammalian cells and mice.

Main Results:

  • Successfully designed and implemented an upconversion optogenetic nanosystem.
  • Demonstrated deep-tissue penetration and activation of optogenetic tools using NIR light.
  • Showcased control over the apoptotic signaling pathway in cancer cells in vivo.

Conclusions:

  • The developed NIR-light-responsive upconversion optogenetic nanotechnology overcomes visible light penetration limitations.
  • This technology holds significant potential for basic research and clinical applications in vivo.
  • Noninvasive, deep-tissue optogenetic manipulation is achievable with this novel nanosystem.