Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stimulants01:29

Stimulants

1.1K
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
1.1K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

2.0K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
2.0K
Drug Regulation01:25

Drug Regulation

3.1K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
3.1K
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

217
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
217

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pre-pregnancy depression, prenatal care, and e-cigarette/cigarette use during late pregnancy among adolescents.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2026
Same author

A Photovoice exploration of youth vaping.

Population medicine·2026
Same author

Relations of residential greenness with immunity and inflammation.

Environmental research·2026
Same author

Cardiovascular disease risk perceptions and tobacco use among Appalachian youth.

Population medicine·2026
Same author

Adolescent cyberbullying and polysubstance use: unpacking sex differences.

Scientific reports·2026
Same author

Lifetime Cannabis, Non-Cigarette Tobacco, and Illicit Drug Use and Cardiovascular Disease Among Young and Middle-Aged U.S. Adults.

American journal of lifestyle medicine·2025

Related Experiment Video

Updated: Feb 20, 2026

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
08:39

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

26.6K

Generally Recognized as Safe: Uncertainty Surrounding E-Cigarette Flavoring Safety.

Clara G Sears1,2, Joy L Hart3,4, Kandi L Walker5,6

  • 1Department of Communication, University of Louisville, Louisville, KY 40292, USA. clara.sears@louisville.edu.

International Journal of Environmental Research and Public Health
|October 26, 2017
PubMed
Summary

Many consumers misunderstand the "generally recognized as safe" (GRAS) designation, believing it applies to e-cigarette flavorings. This misunderstanding persists despite scientific uncertainty about inhalation safety.

Keywords:
GRASe-cige-cigaretteelectronic cigarettevape

More Related Videos

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
09:30

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol

Published on: January 18, 2018

9.0K
Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
10:44

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

12.2K

Related Experiment Videos

Last Updated: Feb 20, 2026

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
08:39

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

26.6K
A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
09:30

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol

Published on: January 18, 2018

9.0K
Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
10:44

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

12.2K

Area of Science:

  • Public Health
  • Consumer Behavior
  • Toxicology

Background:

  • Consumers often perceive e-cigarette flavorings as safe, influenced by the U.S. Food and Drug Administration's (FDA) "generally recognized as safe" (GRAS) designation.
  • Scientific evidence regarding the safety of inhaling e-cigarette aerosol and flavorings remains uncertain.
  • Misinterpretation of the GRAS designation may contribute to a false sense of security among e-cigarette users.

Purpose of the Study:

  • To investigate the relationship between college students' perceptions of e-cigarette flavoring safety and their understanding of the GRAS designation.
  • To assess the extent to which students comprehend the limitations of the GRAS status concerning inhalation.

Main Methods:

  • An online questionnaire was administered to 567 college students in Spring 2017.
  • Data analysis included Chi-square tests and multivariable logistic regression to compare perceptions.
  • Participants' understanding of the GRAS designation and its applicability to e-cigarette flavorings was evaluated.

Main Results:

  • Only 22% of participants correctly understood that GRAS applies to ingestion, not inhalation, injection, or topical use.
  • Among those who considered flavorings GRAS, most understood it meant safe for ingestion but still believed it was safe for inhalation.
  • A significant gap exists between the intended meaning of GRAS and its perceived relevance to e-cigarette safety.

Conclusions:

  • Misunderstanding of the GRAS designation is prevalent among college students regarding e-cigarette flavorings.
  • Public health messaging should clarify that GRAS status is not indicative of safety for inhalation.
  • Educating consumers about the GRAS designation's limitations is crucial for addressing safety concerns related to e-cigarette use.