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Updated: Feb 20, 2026
Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma
Published on: August 9, 2022
The Electrode Modality Development in Pulsed Electric Field Treatment Facilitates Biocellular Mechanism Study and
Chao Cen1, Xinhua Chen1,2
1The Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health and The Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Abstract:
Pulsed electric field treatment is now widely used in diverse biological and medical applications: gene delivery, electrochemotherapy, and cancer therapy. This minimally invasive technique has several advantages over traditional ablation techniques, such as nonthermal elimination and blood vessel spare effect. Different electrodes are subsequently developed for a specific treatment purpose. Here, we provide a systematic review of electrode modality development in pulsed electric field treatment. For electrodes invented for experiment in vitro, sheet electrode and electrode cuvette, electrodes with high-speed fluorescence imaging system, electrodes with patch-clamp, and electrodes with confocal laser scanning microscopy are introduced. For electrodes invented for experiment in vivo, monopolar electrodes, five-needle array electrodes, single-needle bipolar electrode, parallel plate electrodes, and suction electrode are introduced. The pulsed electric field provides a promising treatment for cancer.
