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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Iatrogenic solid tumors following immunosuppressive therapy.

Kossivi Dantey1, Liron Pantanowitz2

  • 1Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212-4756, United States.

Seminars in Diagnostic Pathology
|October 26, 2017
PubMed
Summary

Immunosuppression from medications like post-transplant therapy can raise the risk of rare, virus-induced solid tumors. This review aids in diagnosing these iatrogenic malignancies, including HPV, EBV, MCPyV, and HHV8-associated cancers.

Keywords:
CarcinomaEBVHHV8HPVImmunosuppressionKaposi sarcomaMerkel cell carcinomaOncogenicSoft tissueTransplantVirus

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Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Chronic immunosuppression, often following organ transplantation, is linked to an increased incidence of solid tumors.
  • These iatrogenic malignancies can present atypically and are frequently rare.
  • A significant proportion of these tumors are virally induced.

Purpose of the Study:

  • To review commonly encountered iatrogenic, non-hematopoietic solid tumors in immunosuppressed patients.
  • To provide a practical diagnostic approach for these rare malignancies.
  • To highlight the role of viral oncogenesis in these cancers.

Main Methods:

  • Review of literature on iatrogenic solid tumors in immunosuppressed patients.
  • Focus on viral-induced malignancies.
  • Discussion of diagnostic strategies, including ancillary studies.

Main Results:

  • Identified common viral-induced solid tumors: HPV-associated carcinomas, EBV-associated tumors, Merkel cell carcinoma (MCPyV-related), and Kaposi sarcoma (HHV8-related).
  • Emphasized the diagnostic utility of immunohistochemistry and in-situ hybridization targeting oncogenic viruses.

Conclusions:

  • Iatrogenic immunosuppression elevates the risk of specific viral-associated solid tumors.
  • Accurate diagnosis relies on recognizing these associations and utilizing targeted ancillary studies.
  • Understanding the viral etiology is crucial for managing these rare cancers.