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Effects of benfotiamine and coenzyme Q10 on kidney damage induced gentamicin

Mehmet Alperen Ustuner1, Dilara Kaman1, Neriman Colakoglu2

  • 1Department of Medical Biochemistry, Firat University School of Medicine, Elazığ, Turkey.

Tissue & Cell
|October 26, 2017
PubMed
Abstract

Insights

Benfotiamine (BFT) protects against gentamicin-induced kidney damage by reducing oxidative stress and inflammation. Coenzyme Q10 (CoQ10) showed some protective effects but were less significant than BFT.

Area of Science:

  • Nephrology
  • Pharmacology
  • Toxicology

Background:

  • Gentamicin (GM) is a vital antibiotic for severe infections.
  • GM use is limited by its nephrotoxicity.
  • Investigating protective agents against GM-induced kidney damage is crucial.

Purpose of the Study:

  • To evaluate the protective effects of benfotiamine (BFT) and coenzyme Q10 (CoQ10) against gentamicin-induced nephrotoxicity in rats.
  • To assess the impact of BFT and CoQ10 on oxidative stress and inflammation markers in GM-treated rats.

Main Methods:

  • Rats were administered gentamicin (GM) alone or in combination with BFT or CoQ10 for 8 days.
  • Serum markers of kidney function (urea, creatinine, KIM-1) were measured.
  • Oxidant/antioxidant parameters and histopathological changes in renal tissues were analyzed.

Main Results:

  • GM induced significant nephrotoxicity, marked by elevated creatinine, urea, KIM-1, malondialdehyde, and reduced glutathione.
  • GM treatment led to severe tubular necrosis and hyaline cast accumulation.
  • BFT administration notably normalized kidney function markers and reduced histological damage.
  • CoQ10 showed a trend towards reducing tubular damage but did not significantly alter measured biochemical parameters compared to GM alone.

Conclusions:

  • Benfotiamine (BFT) effectively attenuates gentamicin-induced nephrotoxicity.
  • BFT ameliorates renal injury by mitigating oxidative stress and inflammation.
  • CoQ10 offers some protective effects, but BFT demonstrates superior renoprotective capabilities in this model.
Keywords:
BenfotiamineCoenzyme Q10NephrotoxicityOxidative stress

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