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Updated: Aug 9, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
99mTc by 99Mo produced at the ENEA-FNG facility of 14MeV neutrons
M Capogni1, A Pietropaolo2, L Quintieri1
1ENEA - Department of Fusion and Technology for Nuclear Safety and Security, Frascati R.C. Via Enrico Fermi, 45, I-00044 Frascati (Rome), Italy; ENEA - Italian National Institute of Ionizing Radiation Metrology (INMRI), Casaccia R.C. Via Anguillarese, 301, I-00123 Rome, Italy.
Abstract:
A severe supply crisis of 99Mo, precursor of 99mTc a diagnostic radionuclide largely used in Nuclear Medicine, occurred in 2008-2009 due to repeated shut-down of the two main (aged) fission reactors. An alternative route for producing 99Mo by 100Mo(n,2n)99Mo reaction was investigated at ENEA. The experiment, designed according to Monte Carlo simulations performed with the Fluka code, produced 99Mo by irradiating a natural Molybdenum powdered target with 14MeV neutrons produced at the Frascati Neutron Generator. The 99Mo specific activity was measured at metrological level by γ-ray spectrometry.
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