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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Drug Dosing: Infants and Children01:29

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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
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Bone protective agents in children.

Claire Louise Wood1,2, S Faisal Ahmed3

  • 1Division of Developmental Biology, University of Edinburgh Roslin Institute, Roslin, Midlothian, UK.

Archives of Disease in Childhood
|October 26, 2017
PubMed
Summary
This summary is machine-generated.

Evaluating childhood bone health is crucial for preventing osteoporosis and fractures. This review covers bisphosphonates and other bone protective agents for pediatric use, as no specific treatments are currently licensed for children.

Keywords:
bone diseasetherapeutics

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Area of Science:

  • Pediatric Endocrinology
  • Bone Metabolism
  • Pharmacology

Background:

  • Childhood bone health evaluation is vital for identifying inadequate bone mineralization.
  • Early identification can guide interventions to reduce osteoporosis and fracture risks in children.
  • Currently, no bone-protective agents are specifically licensed for pediatric osteoporosis prevention or treatment.

Purpose of the Study:

  • To review the mechanism of action and clinical use of bisphosphonates in children.
  • To discuss established and novel bone-protective agents for pediatric application.
  • To address the gap in licensed osteoporosis treatments for pediatric populations.

Main Methods:

  • Literature review of bisphosphonates and other bone-protective agents.
  • Analysis of pharmacological mechanisms and clinical evidence in pediatric studies.
  • Synthesis of information on established and emerging treatments for pediatric bone health.

Main Results:

  • Bisphosphonates demonstrate efficacy in improving bone mineral density in children with various conditions.
  • Several other agents are under investigation or used off-label for pediatric bone health.
  • The review highlights the need for further research and potential for new therapeutic options.

Conclusions:

  • Bisphosphonates are a key therapeutic option for pediatric bone health despite lack of specific licensing.
  • Emerging agents show promise for the future management of pediatric osteoporosis.
  • Optimizing bone health in children requires careful consideration of available and novel bone-protective agents.