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Updated: Feb 20, 2026

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading TED
Published on: May 7, 2013
The endoplasmic reticulum, calcium signaling and junction turnover in Sertoli cells
Wayne Vogl1,2, Kevin Lyon2, Arlo Adams3
1Department of Cellular and Physiological SciencesUniversity of British Columbia, British Columbia, Canada vogl@mail.ubc.ca.
Abstract:
The endoplasmic reticulum (ER) forms a continuous network throughout morphologically differentiated Sertoli cells. It is an integral component of intercellular adhesion junctions in this cell type, as well as forming membrane contact sites with the plasma membrane and intracellular organelles. One of the major functions of the ER in cells generally is maintaining calcium homeostasis and generating calcium signals. In this review, we discuss what is currently known about the overall pattern of distribution of the ER in Sertoli cells and the location of calcium regulatory machinery in the various subdomains of the organelle. Current data are consistent with the hypothesis that calcium signaling by the ER of Sertoli cells may play a significant role in events related to junction remodeling that occur in the seminiferous epithelium during spermatogenesis.
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