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[Relationship between Surgical Site Infection(SSI)Incidence and Prognosis in Colorectal Cancer Surgery]
Masano Sagawa1, Hajime Yokomizo, Kazuhiko Yoshimatsu
1Dept. of Surgery, Tokyo Women's Medical University Medical Center East.
Abstract:
We examined the relationship between risk factors for surgical site infections(SSIs)and prognosis in 440 patients who underwent colon cancer surgery. We evaluated factors related to SSIs(GradeB II)and compared survival rates by stage. SSIs were observed in 36 patients. An increased SSI incidence was associated with pulmonary dysfunction, mGPS=2, CONUT≥2, PNI≤40, NLR>4.3, location(rectum), depth of tumor invasion(Bsubserosa, SS), lymph node metastasis, laparotomy, resection of other organs, colostomy, blood loss(large), and operative time(long). Survival rates were lower in Stage II/III patients with SSIs. Preoperative risk judgment is important in colorectal cancer surgery.
Insights
Surgical site infections (SSIs) after colon cancer surgery are linked to poor patient outcomes. Identifying risk factors like pulmonary dysfunction and tumor invasion can help improve survival rates for patients undergoing colorectal cancer surgery.
Area of Science:
- Oncology
- Surgical Infections
- Clinical Prognostics
Background:
- Surgical site infections (SSIs) are a significant complication following colorectal cancer surgery.
- Understanding the risk factors associated with SSIs is crucial for improving patient prognosis.
Purpose of the Study:
- To investigate the relationship between various risk factors and the incidence of SSIs (Grade B II) in patients undergoing colon cancer surgery.
- To evaluate the impact of SSIs on survival rates based on cancer stage.
Main Methods:
- A cohort of 440 patients who underwent colon cancer surgery was analyzed.
- Risk factors for SSIs and survival rates were assessed, comparing patients with and without SSIs across different cancer stages.
Main Results:
- SSIs were identified in 36 patients.
- Increased SSI incidence correlated with factors including pulmonary dysfunction, elevated mGPS, CONUT, low PNI, high NLR, rectal tumor location, deeper tumor invasion, lymph node metastasis, laparotomy, organ resection, colostomy, significant blood loss, and prolonged operative time.
- Stage II/III patients with SSIs exhibited lower survival rates.
Conclusions:
- Preoperative risk assessment is vital for patients undergoing colorectal cancer surgery.
- Identifying and managing SSI risk factors can potentially improve surgical outcomes and survival rates in colon cancer patients.
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