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Updated: Feb 20, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Challenges and discoveries in the total synthesis of complex polyketide natural products
Ian Paterson1, Nelson Yuen Sum Lam1
1University Chemical Laboratory, Cambridge, UK.
Abstract:
Structurally complex polyketide natural products, isolated from a variety of marine and terrestrial sources, continue to provide a valuable source of rewarding targets for the synthetic chemist to tackle. In this account, we provide an overview of the total synthesis of several structurally fascinating polyketides with promising anticancer activity completed in our group based on our versatile asymmetric aldol methodology-spirastrellolide A methyl ester, leiodermatolide, rhizopodin and chivosazole F-and highlight the unanticipated challenges and discoveries encountered.
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