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Alcoholization of pyogenichepatic abscess with absolute alcohol in Bama minipigs
Ru-Gang Zhang1, Xiu-Li Zhang1, Yun-Sheng Yang1
1Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing 100853, P.R. China.
Abstract:
Pyogenic hepatic abscess (PHA) is a rare, but potentially serious disease. At present, ultrasound-guided or computed tomography-guided percutaneous needle aspiration or catheter drainage is appropriate as a first-line treatment. However, it is difficult to aspirate or drain pus and to select the appropriate antibiotic therapy if the abscess consists of thick pus and polymicrobial confections, or its pathogenic bacterium is multidrug resistant and cryptogenic. Case studies of alcoholization provide a novel method to manage PHA. However, the efficacy and safety of this treatment should be further evaluated. In the present study, the therapeutic efficacy and complications of alcoholization for PHAs in Bama minipigs were investigated. PHAs were prospectively treated by ultrasound-guided percutaneous instillation of absolute alcohol in the abscess cavity. The criteria for considering a successful intervention were met in all minipigs subsequent to alcoholization twice within 14 days. The procedures were well tolerated in all animals, and there were no alcoholic adverse effects or procedure-associated complications. In conclusion, ultrasound-guided percutaneous alcoholization is a safe and effective procedure to manage PHA. The problems of thick pus aspiration and selection of an appropriate antibiotic observed in other treatments were resolved effectively using alcoholization. This technique may reduce the treatment period and possibly become a novel strategy for the management of PHA.
Insights
Ultrasound-guided percutaneous alcoholization offers a safe and effective new treatment for pyogenic hepatic abscesses (PHAs). This method successfully managed PHAs in minipigs, resolving issues with thick pus and antibiotic selection.
Area of Science:
- Hepatology
- Interventional Radiology
- Minipig Models
Background:
- Pyogenic hepatic abscess (PHA) is a serious condition.
- Current treatments like percutaneous drainage face challenges with thick pus and multidrug-resistant bacteria.
- Alcoholization presents a novel therapeutic approach requiring further evaluation.
Purpose of the Study:
- To investigate the therapeutic efficacy and safety of ultrasound-guided percutaneous alcoholization for PHAs.
- To evaluate alcoholization as a potential novel management strategy for pyogenic hepatic abscesses.
Main Methods:
- Prospective study involving Bama minipigs with induced PHAs.
- Treatment administered via ultrasound-guided percutaneous instillation of absolute alcohol into the abscess cavity.
- Alcoholization was performed twice within a 14-day period.
Main Results:
- All minipigs achieved successful intervention criteria following alcoholization.
- The procedure was well-tolerated with no adverse effects or complications.
- Alcoholization effectively addressed challenges associated with thick pus and antibiotic selection.
Conclusions:
- Ultrasound-guided percutaneous alcoholization is a safe and effective treatment for PHAs.
- This technique resolves limitations of traditional methods, potentially shortening treatment duration.
- Alcoholization may emerge as a novel strategy for managing pyogenic hepatic abscesses.
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